Olive oil phenolics are dose-dependently absorbed in humans

Postprandial LDL phenolic content and LDL oxidation are modulated by olive oil phenolic compounds in humans.

Olive oil phenolic compounds are potent antioxidants in vitro, but evidence for antioxidant action in vivo is controversial. We examined the role of the phenolic compounds from olive oil on postprandial oxidative stress and LDL antioxidant content. Oral fat loads of 40 mL of similar olive oils, but with high (366 mg/kg), moderate (164 mg/kg), and low (2.7 mg/kg) phenolic content, were administe...

Tyrosol bioavailability in humans after ingestion of virgin olive oil.

1. Kronholm V, Lintrup J. Spectrophotometric investigation of the cerebrospinal fluid in the near-ultraviolet region. Acta Psychiatr Neurol Scand 1960;35: 314–29. 2. Buruma OJS, Janson HLF, van den Bergh FAJTM, Bots GTAM. Blood stained cerebrospinal fluid: traumatic puncture or haemorrhage? J Neurol Neurosurg Psychiatr 1981;44:144–7. 3. Vermeulen M, Gijn van J, Bleijenberg BG. Spectrophotometri...

Chlorogenic acid and caffeic acid are absorbed in humans.

Chlorogenic acid, an ester of caffeic acid and quinic acid, is a major phenolic compound in coffee; daily intake in coffee drinkers is 0.5-1 g. Chlorogenic acid and caffeic acid are antioxidants in vitro and might therefore contribute to the prevention of cardiovascular disease. However, data on the absorption of chlorogenic acid and caffeic acid in humans are lacking. We determined the absorpt...

Processing Technology in Olive Oil and Table Olive Processing Technology in Olive Oil and Table Olive

Olive oil phenolics: effects on DNA oxidation and redox enzyme mRNA in prostate cells.

Hydroxytyrosol, tyrosol and caffeic acid effects on hydrogen peroxide-induced DNA damage, hydroperoxide generation and redox enzyme gene expression were studied in oxidative-stress-sensitive human prostate cells (PC3). Hydroxytyrosol led to lower levels of hydroperoxides, DNA damage, and mRNA levels of classic glutathione peroxidase (GPx) for all the studied concentrations. Only hydroxytyrosol ...